January 15, 2021

White Sox  sign Liam Hendriks as a free agent

January 18, 2021

White Sox  sign Nick Williams

February 01, 2021

White Sox  sign Carlos Rodon as a free agent

February 11, 2021

White Sox  sign Alex McRae as a free agent

White Sox  sign Tim Beckham

White Sox  sign Jonathan Lucroy

March 16, 2021

White Sox  sign Billy Hamilton as a free agent

March 30, 2021

White Sox  sign Jake Lamb as a free agent

April 01, 2021

White Sox  place Eloy Jimenez on the injured list

White Sox  place Adam Engel on the injured list

White Sox  place Jace Fry on the injured list

White Sox  designate Bernardo Flores for assignment

April 07, 2021

White Sox  place Tim Anderson on the injured list

April 08, 2021

White Sox  place Billy Hamilton on the injured list

White Sox  place Jace Fry on the injured list

April 14, 2021

White Sox  place Dylan Cease on the injured list

April 15, 2021

White Sox  designate Nick Williams for assignment

April 18, 2021

White Sox  place Lance Lynn on the injured list

April 27, 2021

White Sox  place Luis Robert on the injured list

April 29, 2021

White Sox  place Garrett Crochet on the injured list

May 04, 2021

White Sox  place Luis Robert on the injured list

May 05, 2021

White Sox  sign Brian Goodwin

May 27, 2021

White Sox  place Luis Robert on the injured list

May 31, 2021

White Sox  place Michael Kopech on the injured list

June 03, 2021

White Sox  place Andrew Vaughn on the injured list

June 06, 2021

White Sox  place Billy Hamilton on the injured list

June 10, 2021

White Sox  place Nick Madrigal on the injured list

June 17, 2021

White Sox  place Adam Eaton on the injured list

June 22, 2021

White Sox  place Adam Engel on the injured list

June 29, 2021

White Sox  place Jake Lamb on the injured list

June 30, 2021

White Sox  place Aaron Bummer on the injured list

White Sox  place Evan Marshall on the injured list

July 06, 2021

White Sox  place Yasmani Grandal on the injured list

July 07, 2021

White Sox  designate Adam Eaton for assignment

July 13, 2021

White Sox  release Adam Eaton

July 29, 2021

White Sox  place Evan Marshall on the injured list

Ryan Tepera traded from Cubs  to White Sox 

White Sox  sign Kyle Crick

July 30, 2021

August 01, 2021

White Sox  place Billy Hamilton on the injured list

August 09, 2021

White Sox  release Luis Gonzalez

August 11, 2021

White Sox  place Carlos Rodon on the injured list

August 15, 2021

White Sox  place Leury Garcia on the injured list

August 16, 2021

White Sox  place Adam Engel on the injured list

White Sox  designate Zack Burdi for assignment

August 22, 2021

White Sox  place Leury Garcia on the injured list

August 31, 2021

White Sox  place Lance Lynn on the injured list

White Sox  sign Carl Edwards

September 01, 2021

White Sox  place Tim Anderson on the injured list

White Sox  designate Jake Lamb for assignment

September 03, 2021

White Sox  place Lucas Giolito on the injured list

September 14, 2021

White Sox  place Andrew Vaughn on the injured list

White Sox  place Ryan Tepera on the injured list

September 26, 2021

White Sox  place Brian Goodwin on the injured list

October 01, 2021

White Sox  designate Mike Wright for assignment

November 03, 2021

Ryan Tepera became a free agent

Billy Hamilton became a free agent

Leury Garcia became a free agent

Carlos Rodon became a free agent

November 06, 2021

Cesar Hernandez became a free agent

November 30, 2021

White Sox  sign Kyle Crick

White Sox  sign Kendall Graveman as a free agent

December 01, 2021

White Sox  sign Leury Garcia as a free agent

December 03, 2021

White Sox  sign Yacksel Rios