March 14, 2022

Guardians  sign Luke Maile as a free agent

March 17, 2022

Guardians  sign Jake Jewell

Guardians  sign Ian Gibaut

March 25, 2022

Guardians  place Cody Morris on the injured list

Guardians  sign Bryan Shaw as a free agent

March 31, 2022

Guardians  release Sandy Leon

April 04, 2022

Guardians  place James Karinchak on the injured list

Guardians  place Josh Naylor on the injured list

Guardians  place Luke Maile on the injured list

April 08, 2022

April 09, 2022

Guardians  place Anthony Castro on the injured list

April 15, 2022

Guardians  place Yu Chang on the injured list

May 02, 2022

Guardians  designate Logan Allen for assignment

Guardians  designate Bobby Bradley for assignment

May 03, 2022

Guardians  sign Anthony Alford

May 13, 2022

Guardians  place Josh Naylor on the injured list

May 16, 2022

Yohan Ramirez traded from Mariners  to Guardians 

May 20, 2022

Guardians  designate Luis Oviedo for assignment

May 25, 2022

Guardians  place Aaron Civale on the injured list

Daniel Johnson traded from Guardians  to Mets 

May 26, 2022

Guardians  place Franmil Reyes on the injured list

Guardians  designate Yu Chang for assignment

May 30, 2022

Yu Chang traded from Guardians  to Pirates 

June 21, 2022

Guardians  designate Oscar Mercado for assignment

June 27, 2022

Guardians  designate Tanner Tully for assignment

June 28, 2022

Guardians  place Austin Hedges on the injured list

Guardians  designate Ian Gibaut for assignment

Sandy Leon traded from Reds  to Guardians 

July 02, 2022

Guardians  place Oscar Gonzalez on the injured list

July 03, 2022

Guardians  place Anthony Gose on the injured list

Guardians  designate Kirk McCarty for assignment

July 04, 2022

Guardians  designate Yohan Ramirez for assignment

July 08, 2022

Guardians  designate Sandy Leon for assignment

Yohan Ramirez traded from Guardians  to Pirates 

July 11, 2022

Guardians  designate Oscar Mercado for assignment

July 14, 2022

Guardians  designate Alex Young for assignment

Guardians  place Aaron Civale on the injured list

July 18, 2022

Guardians  designate Tanner Tully for assignment

Alex Young traded from Guardians  to Giants 

August 02, 2022

August 05, 2022

Guardians  designate Alex Call for assignment

August 06, 2022

Guardians  designate Franmil Reyes for assignment

August 15, 2022

Guardians  designate Jake Jewell for assignment

September 01, 2022

Guardians  designate Anthony Castro for assignment

September 02, 2022

Guardians  place Aaron Civale on the injured list

Guardians  place Zach Plesac on the injured list

September 21, 2022

Guardians  designate Ernie Clement for assignment

October 01, 2022

Guardians  designate Bryan Shaw for assignment

November 06, 2022

Austin Hedges became a free agent

November 15, 2022

Guardians  designate Kirk McCarty for assignment

Guardians  designate Anthony Gose for assignment

Nolan Jones traded from Guardians  to Rockies 

November 17, 2022

Guardians  release Kirk McCarty

November 18, 2022

Anthony Gose became a free agent

Luke Maile became a free agent