January 29, 2021

Indians  sign Cesar Hernandez as a free agent

February 03, 2021

Indians  sign Bryan Shaw as a free agent

Indians  sign DJ Johnson

February 04, 2021

Indians  sign Eddie Rosario as a free agent

Indians  sign Mike Freeman

February 12, 2021

Indians  sign Ben Gamel

February 15, 2021

Indians  sign Billy Hamilton

February 16, 2021

Indians  sign Blake Parker as a free agent

February 18, 2021

Indians  sign Oliver Perez

February 19, 2021

Indians  sign Ryan Lavarnway

March 12, 2021

Mike Freeman traded from Indians  to Reds 

March 13, 2021

Indians  release Billy Hamilton

March 27, 2021

Adam Plutko traded from Indians  to Orioles 

April 14, 2021

Indians  sign Rene Rivera as a free agent

April 23, 2021

Indians  sign Matt Koch

April 28, 2021

Indians  designate Oliver Perez for assignment

May 05, 2021

Indians  place Roberto Perez on the injured list

Indians  designate Ben Gamel for assignment

May 23, 2021

Indians  place Franmil Reyes on the injured list

Indians  place Roberto Perez on the injured list

May 25, 2021

Indians  sign Kevin Herget

May 26, 2021

Indians  place Zach Plesac on the injured list

May 28, 2021

Indians  place Jordan Luplow on the injured list

June 05, 2021

Indians  designate Jake Bauers for assignment

June 10, 2021

Jake Bauers traded from Indians  to Mariners 

June 14, 2021

Indians  place Shane Bieber on the injured list

June 17, 2021

Indians  place Austin Hedges on the injured list

Indians  place Jordan Luplow on the injured list

June 24, 2021

Indians  place Aaron Civale on the injured list

Indians  designate Ryan Lavarnway for assignment

June 25, 2021

Indians  sign Brad Peacock

June 28, 2021

Indians  place Josh Naylor on the injured list

June 29, 2021

Indians  sign Zack Godley

July 03, 2021

Indians  designate Rene Rivera for assignment

July 06, 2021

Indians  sign Wilson Ramos

July 07, 2021

Indians  place Eddie Rosario on the injured list

Indians  place Josh Naylor on the injured list

July 08, 2021

Indians  release Rene Rivera

July 25, 2021

Indians  place Shane Bieber on the injured list

July 26, 2021

Indians  place Aaron Civale on the injured list

July 29, 2021

July 30, 2021

Indians  release Pablo Sandoval

July 31, 2021

Indians  designate Justin Garza for assignment

August 06, 2021

Indians  place Roberto Perez on the injured list

August 09, 2021

Indians  place Bobby Bradley on the injured list

August 12, 2021

Indians  place Nick Sandlin on the injured list

August 13, 2021

Indians  place Harold Ramirez on the injured list

August 25, 2021

Indians  place Triston McKenzie on the injured list

August 26, 2021

Indians  place Ernie Clement on the injured list

August 30, 2021

Brad Peacock traded from Indians  to Red Sox 

August 31, 2021

Indians  place Wilson Ramos on the injured list

September 01, 2021

Indians  designate Harold Ramirez for assignment

September 14, 2021

Indians  designate Ryan Lavarnway for assignment

September 20, 2021

Indians  place Amed Rosario on the injured list

September 24, 2021

Indians  place Nick Sandlin on the injured list

October 05, 2021

Indians  designate Kyle Nelson for assignment

Indians  designate J.C. Mejia for assignment

Indians  designate Alex Young for assignment

Indians  designate Daniel Johnson for assignment

November 03, 2021

Bryan Shaw became a free agent

Blake Parker became a free agent

Wilson Ramos became a free agent

November 05, 2021

Roberto Perez became a free agent

November 07, 2021

Indians  sign Oscar Gonzalez

November 22, 2021

Harold Ramirez traded from Indians  to Cubs 

J.C. Mejia traded from Indians  to Brewers 

Indians  sign Sandy Leon as a free agent

December 01, 2021

Indians  sign Enyel De Los Santos