January 07, 2021

Astros  sign Ryne Stanek as a free agent

January 15, 2021

Astros  sign Pedro Baez as a free agent

January 22, 2021

Astros  designate Humberto Castellanos for assignment

Astros  sign Jason Castro as a free agent

January 23, 2021

Cionel Perez traded from Astros  to Reds 

January 25, 2021

Astros  sign Michael Brantley as a free agent

February 01, 2021

Astros  sign Steven Souza

February 09, 2021

Astros  sign Steve Cishek

February 27, 2021

Astros  place Justin Verlander on the injured list

March 08, 2021

Astros  place Pedro Baez on the injured list

Astros  sign Jake Odorizzi as a free agent

April 01, 2021

Astros  place Austin Pruitt on the injured list

Astros  place Josh James on the injured list

Astros  place Framber Valdez on the injured list

Astros  place Andre Scrubb on the injured list

April 09, 2021

Astros  place Enoli Paredes on the injured list

April 10, 2021

Astros  place Austin Pruitt on the injured list

Astros  place Pedro Baez on the injured list

April 14, 2021

Astros  place Jose Altuve on the injured list

Astros  place Martin Maldonado on the injured list

Astros  place Alex Bregman on the injured list

Astros  place Yordan Alvarez on the injured list

Astros  place Robel Garcia on the injured list

April 17, 2021

Astros  place Blake Taylor on the injured list

April 20, 2021

Astros  place Taylor Jones on the injured list

April 26, 2021

Astros  place Jake Odorizzi on the injured list

Astros  place Pedro Baez on the injured list

April 28, 2021

Astros  place Yordan Alvarez on the injured list

May 11, 2021

Astros  sign Michael Kelly

May 16, 2021

Astros  place Jose Urquidy on the injured list

May 26, 2021

Astros  place Lance McCullers on the injured list

Astros  place Josh James on the injured list

May 28, 2021

Astros  place Jason Castro on the injured list

Astros  place Michael Brantley on the injured list

Astros  place Kent Emanuel on the injured list

May 30, 2021

Astros  place Bryan Abreu on the injured list

June 08, 2021

Astros  place Aledmys Diaz on the injured list

June 09, 2021

Astros  place Joe Smith on the injured list

June 11, 2021

Astros  place Enoli Paredes on the injured list

June 16, 2021

Astros  place Kyle Tucker on the injured list

June 17, 2021

Astros  place Alex Bregman on the injured list

June 23, 2021

Astros  place Kent Emanuel on the injured list

June 30, 2021

Astros  place Jose Urquidy on the injured list

July 08, 2021

Astros  place Brooks Raley on the injured list

July 09, 2021

Astros  place Carlos Correa on the injured list

July 19, 2021

Astros  place Andre Scrubb on the injured list

July 25, 2021

Astros  designate Ryan Hartman for assignment

July 27, 2021

July 28, 2021

Astros  designate Austin Pruitt for assignment

July 30, 2021

July 31, 2021

Astros  designate Nivaldo Rodriguez for assignment

August 01, 2021

Astros  designate Ralph Garza Jr. for assignment

August 02, 2021

Astros  place Tyler Ivey on the injured list

August 06, 2021

Astros  place Yuli Gurriel on the injured list

August 10, 2021

Astros  place Andre Scrubb on the injured list

Astros  place Rafael Montero on the injured list

August 14, 2021

Astros  place Kyle Tucker on the injured list

August 24, 2021

Astros  place Chas McCormick on the injured list

Astros  place Pedro Baez on the injured list

August 27, 2021

Astros  sign Marwin Gonzalez

August 29, 2021

Astros  place Jason Castro on the injured list

August 31, 2021

Astros  place Zack Greinke on the injured list

Astros  place Taylor Jones on the injured list

Astros  sign Drew Butera

September 14, 2021

Astros  place Jake Odorizzi on the injured list

September 15, 2021

Astros  place Michael Brantley on the injured list

Astros  place Rafael Montero on the injured list

Astros  designate Robel Garcia for assignment

September 24, 2021

Astros  place Zack Greinke on the injured list

October 30, 2021

Astros  place Jason Castro on the injured list

November 03, 2021

Justin Verlander became a free agent

Marwin Gonzalez became a free agent

Brooks Raley became a free agent

Kendall Graveman became a free agent

Yimi Garcia became a free agent

Carlos Correa became a free agent

Zack Greinke became a free agent

November 19, 2021

Garrett Stubbs traded from Astros  to Phillies 

December 01, 2021

Astros  sign Hector Neris as a free agent