January 22, 2021

Twins  sign J.A. Happ as a free agent

January 31, 2021

Twins  sign Andrelton Simmons as a free agent

February 04, 2021

Shaun Anderson traded from None  to Twins 

LaMonte Wade traded from Twins  to Giants 

February 05, 2021

Twins  sign Nelson Cruz as a free agent

February 11, 2021

Twins  designate Brandon Waddell for assignment

February 12, 2021

Twins  designate Ian Hamilton for assignment

Twins  sign Alex Colome as a free agent

Twins  sign Andrew Albers

February 15, 2021

Twins  sign Jermaine Palacios

February 18, 2021

Twins  sign Matt Shoemaker as a free agent

February 22, 2021

Twins  sign Andrew Romine

March 25, 2021

Twins  release Andrew Romine

April 03, 2021

Twins  place Josh Donaldson on the injured list

April 07, 2021

Twins  place Brent Rooker on the injured list

April 14, 2021

Twins  place Andrelton Simmons on the injured list

April 20, 2021

Twins  place Caleb Thielbar on the injured list

Twins  place Max Kepler on the injured list

Twins  place Kyle Garlick on the injured list

April 21, 2021

Twins  place Miguel Sano on the injured list

Twins  place JT Riddle on the injured list

April 23, 2021

Twins  place Miguel Sano on the injured list

April 29, 2021

Twins  designate Tzu-Wei Lin for assignment

Twins  designate JT Riddle for assignment

May 04, 2021

Twins  place Luis Arraez on the injured list

May 05, 2021

Twins  place Alex Kirilloff on the injured list

May 07, 2021

Twins  place Byron Buxton on the injured list

Twins  designate Brandon Waddell for assignment

May 08, 2021

Twins  designate Travis Blankenhorn for assignment

May 12, 2021

Twins  place Devin Smeltzer on the injured list

May 15, 2021

Twins  place Jake Cave on the injured list

May 18, 2021

Twins  place Shaun Anderson on the injured list

Twins  designate Derek Law for assignment

May 19, 2021

Twins  place Michael Pineda on the injured list

May 23, 2021

Twins  place Kenta Maeda on the injured list

May 26, 2021

Twins  place Luis Arraez on the injured list

May 30, 2021

Twins  place Max Kepler on the injured list

June 02, 2021

Twins  place Mitch Garver on the injured list

Twins  place Rob Refsnyder on the injured list

June 03, 2021

Twins  place Caleb Thielbar on the injured list

June 05, 2021

Twins  designate Juan Minaya for assignment

June 06, 2021

Twins  place Shaun Anderson on the injured list

June 08, 2021

Twins  place Cody Stashak on the injured list

June 09, 2021

Twins  place Kyle Garlick on the injured list

June 14, 2021

Twins  place Michael Pineda on the injured list

Twins  place Rob Refsnyder on the injured list

June 20, 2021

Twins  sign Kyle Barraclough

June 22, 2021

Twins  place Byron Buxton on the injured list

June 23, 2021

Twins  sign Nick Vincent

June 24, 2021

Twins  place Randy Dobnak on the injured list

June 25, 2021

Twins  place Cody Stashak on the injured list

Twins  place Luke Farrell on the injured list

July 01, 2021

Twins  designate Matt Shoemaker for assignment

July 02, 2021

Twins  sign Joe Harvey

July 16, 2021

Twins  place Devin Smeltzer on the injured list

July 17, 2021

Twins  place Randy Dobnak on the injured list

Twins  place Derek Law on the injured list

July 21, 2021

Twins  place Alex Kirilloff on the injured list

July 22, 2021

July 24, 2021

Twins  place Kyle Garlick on the injured list

Twins  place Luis Arraez on the injured list

July 27, 2021

Twins  place Taylor Rogers on the injured list

July 30, 2021

Hansel Robles traded from Twins  to Red Sox 

August 09, 2021

Twins  place Jorge Alcala on the injured list

August 10, 2021

Twins  place Alex Kirilloff on the injured list

August 14, 2021

Twins  place Michael Pineda on the injured list

August 18, 2021

Twins  designate Nick Vincent for assignment

August 19, 2021

Twins  place Lewis Thorpe on the injured list

August 23, 2021

Twins  place Kenta Maeda on the injured list

August 27, 2021

Twins  place Luke Farrell on the injured list

Twins  place Mitch Garver on the injured list

August 31, 2021

Andrew Vasquez traded from Twins  to Dodgers 

Twins  sign Vinny Nittoli

September 01, 2021

Twins  place Kenta Maeda on the injured list

September 05, 2021

Twins  designate Derek Law for assignment

September 09, 2021

Twins  place Randy Dobnak on the injured list

September 11, 2021

Twins  place Randy Dobnak on the injured list

September 14, 2021

Twins  place John Gant on the injured list

September 18, 2021

Twins  place Rob Refsnyder on the injured list

Twins  place Taylor Rogers on the injured list

September 20, 2021

Twins  place Lewis Thorpe on the injured list

September 28, 2021

Twins  place Bailey Ober on the injured list

October 02, 2021

Twins  place John Gant on the injured list

November 03, 2021

Michael Pineda became a free agent

Andrelton Simmons became a free agent

November 05, 2021

Alex Colome became a free agent

John Gant became a free agent

November 23, 2021

Twins  release Willians Astudillo

November 30, 2021

Danny Coulombe became a free agent

Jharel Cotton became a free agent

Juan Minaya became a free agent

Trevor Megill became a free agent

Twins  sign Curtis Terry

December 01, 2021

Twins  sign Jake Faria

Twins  sign Trevor Megill

Twins  sign Dylan Bundy as a free agent

Twins  sign Jharel Cotton as a free agent

Twins  sign Danny Coulombe

December 15, 2021

Twins  sign Derek Fisher