January 05, 2021

Pirates  sign Chase De Jong

January 15, 2021

Pirates  sign Wilmer Difo as a free agent

January 19, 2021

January 24, 2021

Pirates  designate Troy Stokes Jr. for assignment

February 07, 2021

Pirates  sign Chasen Shreve as a free agent

February 11, 2021

Pirates  sign Tony Wolters

Pirates  sign Brian Goodwin

February 17, 2021

Pirates  sign Tyler Anderson as a free agent

February 20, 2021

Pirates  sign Todd Frazier

February 24, 2021

Pirates  place Austin Davis on the injured list

Dustin Fowler traded from Athletics  to Pirates 

March 07, 2021

Pirates  designate Carson Fulmer for assignment

Duane Underwood traded from Cubs  to Pirates 

March 12, 2021

Pirates  sign Trevor Cahill as a free agent

March 27, 2021

Pirates  release Todd Frazier

March 29, 2021

Pirates  release Tony Wolters

March 30, 2021

Pirates  sign Todd Frazier as a free agent

April 01, 2021

Pirates  place Kyle Crick on the injured list

Pirates  place Steven Brault on the injured list

Pirates  place Cody Ponce on the injured list

April 04, 2021

Pirates  place Ke'Bryan Hayes on the injured list

April 05, 2021

Pirates  designate Edgar Santana for assignment

Kyle Keller traded from Angels  to Pirates 

April 09, 2021

Edgar Santana traded from Pirates  to Braves 

April 16, 2021

Pirates  place Michael Feliz on the injured list

April 21, 2021

Pirates  designate Anthony Alford for assignment

April 22, 2021

Pirates  place Chad Kuhl on the injured list

Pirates  designate Dustin Fowler for assignment

April 23, 2021

Pirates  place Ka'ai Tom on the injured list

May 01, 2021

Pirates  sign Christian Bethancourt

May 04, 2021

Pirates  place Gregory Polanco on the injured list

May 09, 2021

Pirates  place Colin Moran on the injured list

Pirates  place Ke'Bryan Hayes on the injured list

Pirates  designate Michael Feliz for assignment

May 10, 2021

Pirates  designate Todd Frazier for assignment

May 11, 2021

Pirates  place Kyle Crick on the injured list

Pirates  designate Hunter Owen for assignment

May 13, 2021

Pirates  place Phillip Evans on the injured list

Pirates  designate Sean Poppen for assignment

May 17, 2021

Pirates  designate Troy Stokes Jr. for assignment

May 18, 2021

Sean Poppen traded from Pirates  to Rays 

May 21, 2021

Pirates  place Ka'ai Tom on the injured list

May 22, 2021

Pirates  place Trevor Cahill on the injured list

May 30, 2021

Pirates  designate Ildemaro Vargas for assignment

June 02, 2021

Ildemaro Vargas traded from Pirates  to Diamondbacks 

June 03, 2021

Pirates  place JT Brubaker on the injured list

June 04, 2021

Pirates  designate Will Craig for assignment

June 06, 2021

Pirates  place Mitch Keller on the injured list

June 08, 2021

Pirates  designate Wilmer Difo for assignment

June 10, 2021

Pirates  place Luis Oviedo on the injured list

June 12, 2021

Pirates  place Trevor Cahill on the injured list

June 15, 2021

Taylor Davis traded from Orioles  to Pirates 

June 20, 2021

Pirates  place Sam Howard on the injured list

June 25, 2021

July 01, 2021

Pirates  place Colin Moran on the injured list

Pirates  sign Shelby Miller

July 02, 2021

Pirates  place Erik Gonzalez on the injured list

Pirates  place Trevor Cahill on the injured list

July 03, 2021

Pirates  place Ka'ai Tom on the injured list

Pirates  designate Geoff Hartlieb for assignment

John Nogowski traded from Cardinals  to Pirates 

July 05, 2021

Pirates  sign Tanner Anderson

July 06, 2021

Pirates  place Phillip Evans on the injured list

Pirates  place Gregory Polanco on the injured list

July 08, 2021

Pirates  sign Dee Strange-Gordon

July 09, 2021

Pirates  place Duane Underwood on the injured list

July 13, 2021

Pirates  place Sam Howard on the injured list

July 19, 2021

Pirates  designate Kyle Crick for assignment

Dillon Peters traded from Angels  to Pirates 

July 20, 2021

Pirates  place Chase De Jong on the injured list

July 24, 2021

Pirates  release Kyle Crick

July 26, 2021

July 28, 2021

Tyler Anderson traded from Pirates  to Mariners 

July 30, 2021

August 02, 2021

Pirates  place Chad Kuhl on the injured list

August 03, 2021

Pirates  place Anthony Banda on the injured list

Pirates  sign Keury Mella

August 04, 2021

Pirates  place Chase De Jong on the injured list

August 06, 2021

Pirates  place Ben Gamel on the injured list

August 07, 2021

Pirates  designate Erik Gonzalez for assignment

August 15, 2021

Pirates  place Bryse Wilson on the injured list

Pirates  place Anthony Alford on the injured list

August 16, 2021

Pirates  designate Ka'ai Tom for assignment

Pirates  designate John Nogowski for assignment

Pirates  sign Yoshi Tsutsugo

August 25, 2021

Pirates  place JT Brubaker on the injured list

August 28, 2021

Pirates  place Dillon Peters on the injured list

Pirates  designate Gregory Polanco for assignment

August 29, 2021

Pirates  place Michael Chavis on the injured list

August 31, 2021

Pirates  place Michael Chavis on the injured list

September 05, 2021

Pirates  place JT Brubaker on the injured list

Pirates  place Duane Underwood on the injured list

September 06, 2021

Pirates  place Duane Underwood on the injured list

September 11, 2021

Pirates  place Steven Brault on the injured list

September 13, 2021

Pirates  place Steven Brault on the injured list

September 14, 2021

Pirates  place David Bednar on the injured list

September 19, 2021

Pirates  place Bryse Wilson on the injured list

September 20, 2021

Pirates  place Bryse Wilson on the injured list

Pirates  place Jacob Stallings on the injured list

September 24, 2021

Pirates  place Dillon Peters on the injured list

September 27, 2021

Pirates  place Luis Oviedo on the injured list

September 28, 2021

Pirates  place Connor Overton on the injured list

September 29, 2021

Pirates  place Ke'Bryan Hayes on the injured list

September 30, 2021

Pirates  place Dillon Peters on the injured list

October 02, 2021

Pirates  place Tanner Anderson on the injured list

October 05, 2021

Pirates  release Tanner Anderson

Pirates  release Phillip Evans

November 03, 2021

Trevor Cahill became a free agent

Shelby Miller became a free agent

Yoshi Tsutsugo became a free agent

November 05, 2021

Chasen Shreve became a free agent

November 16, 2021

Pirates  release Taylor Davis

November 19, 2021

Pirates  designate Michael Perez for assignment

November 28, 2021

Pirates  sign Jerad Eickhoff

November 29, 2021

Pirates  designate Colin Moran for assignment

Pirates  designate Steven Brault for assignment

Pirates  release Cody Ponce

Pirates  sign Yoshi Tsutsugo as a free agent

Pirates  sign Jose Quintana as a free agent

November 30, 2021

Steven Brault became a free agent

Colin Moran became a free agent

Chad Kuhl became a free agent

December 01, 2021

Pirates  sign Roberto Perez as a free agent