January 12, 2021

Blue Jays  sign A.J. Cole as a free agent

January 20, 2021

Blue Jays  sign Kirby Yates as a free agent

January 21, 2021

Blue Jays  designate Anthony Castro for assignment

Blue Jays  sign Tyler Chatwood as a free agent

January 23, 2021

Blue Jays  sign George Springer as a free agent

January 27, 2021

January 30, 2021

Blue Jays  sign Marcus Semien as a free agent

February 02, 2021

Blue Jays  sign Connor Overton

February 11, 2021

Blue Jays  designate Derek Fisher for assignment

Blue Jays  sign David Phelps as a free agent

February 12, 2021

Blue Jays  sign Joe Panik

February 15, 2021

Derek Fisher traded from Blue Jays  to Brewers 

February 25, 2021

Blue Jays  sign Tommy Milone as a free agent

February 28, 2021

Blue Jays  place Patrick Murphy on the injured list

Travis Bergen traded from Diamondbacks  to Blue Jays 

April 01, 2021

Blue Jays  place George Springer on the injured list

Blue Jays  place Nate Pearson on the injured list

Blue Jays  place Tom Hatch on the injured list

Blue Jays  place Kirby Yates on the injured list

Blue Jays  place Robbie Ray on the injured list

Blue Jays  designate Breyvic Valera for assignment

Blue Jays  designate Reese McGuire for assignment

April 04, 2021

Blue Jays  place Kirby Yates on the injured list

April 09, 2021

Blue Jays  place Teoscar Hernandez on the injured list

Blue Jays  place Ryan Borucki on the injured list

Blue Jays  place Tyler Chatwood on the injured list

April 10, 2021

Blue Jays  place Lourdes Gurriel on the injured list

April 14, 2021

Blue Jays  place Julian Merryweather on the injured list

April 15, 2021

Blue Jays  place Ross Stripling on the injured list

Blue Jays  place Jordan Romano on the injured list

April 20, 2021

Blue Jays  place T.J. Zeuch on the injured list

April 22, 2021

Blue Jays  place Tom Hatch on the injured list

Jeremy Beasley traded from Diamondbacks  to Blue Jays 

April 28, 2021

Blue Jays  place Hyun Jin Ryu on the injured list

April 30, 2021

Blue Jays  designate Tanner Roark for assignment

May 02, 2021

Blue Jays  place Alejandro Kirk on the injured list

Blue Jays  place Tommy Milone on the injured list

Blue Jays  place Anthony Castro on the injured list

May 03, 2021

Blue Jays  release Tanner Roark

May 05, 2021

Blue Jays  place Julian Merryweather on the injured list

Blue Jays  place George Springer on the injured list

May 06, 2021

Blue Jays  place David Phelps on the injured list

May 07, 2021

Blue Jays  place Joe Panik on the injured list

May 08, 2021

Blue Jays  place Alejandro Kirk on the injured list

May 09, 2021

Blue Jays  place Rafael Dolis on the injured list

May 14, 2021

Blue Jays  place Ryan Borucki on the injured list

Blue Jays  sign Carl Edwards

May 15, 2021

Blue Jays  place David Phelps on the injured list

May 22, 2021

Blue Jays  place Anthony Kay on the injured list

Blue Jays  place Cavan Biggio on the injured list

May 27, 2021

Blue Jays  place Travis Bergen on the injured list

Blue Jays  place Tommy Milone on the injured list

May 30, 2021

Blue Jays  designate Ty Tice for assignment

Blue Jays  sign Jared Hoying

June 02, 2021

Blue Jays  place A.J. Cole on the injured list

June 04, 2021

Ty Tice traded from Blue Jays  to Braves 

June 08, 2021

Blue Jays  place Danny Jansen on the injured list

June 12, 2021

Blue Jays  place A.J. Cole on the injured list

June 13, 2021

Blue Jays  place Steven Matz on the injured list

June 16, 2021

Blue Jays  place Carl Edwards on the injured list

June 17, 2021

Blue Jays  place Carl Edwards on the injured list

Blue Jays  place Rafael Dolis on the injured list

June 19, 2021

Jacob Barnes traded from Mets  to Blue Jays 

June 24, 2021

Blue Jays  sign John Axford

June 29, 2021

Blue Jays  designate Travis Bergen for assignment

June 30, 2021

Blue Jays  designate Jeremy Beasley for assignment

July 02, 2021

Blue Jays  place Tyler Chatwood on the injured list

July 06, 2021

Blue Jays  place Ryan Borucki on the injured list

July 16, 2021

Blue Jays  designate Joel Payamps for assignment

July 18, 2021

Blue Jays  designate Nick Allgeyer for assignment

July 19, 2021

Blue Jays  place Alek Manoah on the injured list

Blue Jays  place Anthony Castro on the injured list

July 20, 2021

Blue Jays  designate T.J. Zeuch for assignment

July 21, 2021

Joel Payamps traded from Blue Jays  to Royals 

July 23, 2021

Blue Jays  place Danny Jansen on the injured list

July 25, 2021

T.J. Zeuch traded from Blue Jays  to Cardinals 

July 26, 2021

Blue Jays  designate Jacob Barnes for assignment

July 29, 2021

July 30, 2021

Blue Jays  designate Jonathan Davis for assignment

Blue Jays  designate Tyler Chatwood for assignment

Joakim Soria traded from Diamondbacks  to Blue Jays 

July 31, 2021

Blue Jays  release Tyler Chatwood

August 02, 2021

John Axford traded from Blue Jays  to Brewers 

August 03, 2021

Blue Jays  place Cavan Biggio on the injured list

August 04, 2021

Blue Jays  place Joakim Soria on the injured list

August 07, 2021

Blue Jays  place Tim Mayza on the injured list

August 10, 2021

Blue Jays  release Tommy Milone

August 11, 2021

Blue Jays  place Ross Stripling on the injured list

Blue Jays  designate Patrick Murphy for assignment

August 17, 2021

Blue Jays  place George Springer on the injured list

August 18, 2021

Blue Jays  designate Rafael Dolis for assignment

August 29, 2021

Blue Jays  place Santiago Espinal on the injured list

Blue Jays  release Carl Edwards

August 31, 2021

Blue Jays  designate Brad Hand for assignment

Blue Jays  sign Gregory Polanco

September 03, 2021

Blue Jays  designate Connor Overton for assignment

September 08, 2021

Blue Jays  place Anthony Kay on the injured list

September 19, 2021

Blue Jays  place Hyun Jin Ryu on the injured list

September 22, 2021

Blue Jays  place Breyvic Valera on the injured list

September 23, 2021

Blue Jays  designate Jake Lamb for assignment

September 24, 2021

Blue Jays  place Tom Hatch on the injured list

September 25, 2021

Blue Jays  place Joakim Soria on the injured list

September 29, 2021

Blue Jays  release Jake Lamb

October 05, 2021

Dany Jimenez became a free agent

Travis Bergen became a free agent

A.J. Cole became a free agent

October 20, 2021

Blue Jays  designate Jacob Barnes for assignment

November 03, 2021

David Phelps became a free agent

Kirby Yates became a free agent

Joakim Soria became a free agent

Jarrod Dyson became a free agent

Marcus Semien became a free agent

Robbie Ray became a free agent

Corey Dickerson became a free agent

Steven Matz became a free agent

November 29, 2021

Blue Jays  sign Matt Gage

Blue Jays  sign Casey Lawrence

Blue Jays  sign David Phelps

Blue Jays  sign Jose De Leon

November 30, 2021

Blue Jays  release Breyvic Valera

December 01, 2021

Blue Jays  sign Kevin Gausman as a free agent

Blue Jays  sign Yimi Garcia as a free agent

December 16, 2021

Blue Jays  sign Gosuke Katoh